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Although it remains to be seen whether VIA activity is a true correlate of HIV protection, VIA activity has been shown to be associated with control of HIV [21], [23], [24].
Could the activation in the medial postcentral area be due to a confound in our task, rather than a true correlate of experience of free choice?
In the absence of a true correlate, functional markers such as gamma interferon (IFN-γ) expression are measured to assess vaccine immunogenicity.
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Although individual approaches have begun to shed light on mechanisms involved in vaccine-conferred protection from infection, true correlates of protection have not yet been identified.
As for statistical methods, variable-selection technologies are continuing to evolve, in particular with regard to their "oracle" properties, which is their ability to identify true correlates with immune response.
Detailed studies will be published elsewhere, comparing a broad range of immunological parameters across the 3 treatment arms aimed at identifying true correlates of disease and elucidating the pathogenesis of the vasculopathy more clearly.
If true, correlates of TB progression should be identifiable, and these could be valuable in early identification of individuals at risk of developing – and transmitting – TB (Ottenhoff et al., 2012a).
While traditional microarray experiments strive to establish the 'global view' of the activity of all genes (i.e., the genome) in response to environmental conditions, they may also be used to characterize and quantitatively describe gene expression behavior of a selected set of genes as a true genotypic correlate of a particular phenotype.
A ρ of 0 means that there is no correlation between the two maps, which is true when correlating with random fixation-distance maps.
True immune correlates of controlled HIV infection remain obscure.
Moreover, this population showed broad distributions of most of the indices measured, favoring the detection of true biologic correlates (Hb 68-133 g/L; hepcidin 0.2-94 0.2-94 CRP 0.6-121 mg/L; ferriting/mL11 ng/mL; serum iron 6-27 μmol/L; sTfR 3-34 mg/L; sTfR-F index 1-59; erythropoietin 4-196 mIU/mL; ZnPP 51-347 mmol/mol Hb; iron inCRPporation, 1%-68%).
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