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This supports the general validity of the gene-wide approach for detecting true association signals.
"If this is a true association, that's one more lifestyle change women can make".
Misclassification in some studies could have influenced the association, causing it to appear weaker than the true association.
However, we are confident that this reflects a true association and is not a false positive signal for two reasons.
The photograph has no true association with the featured article.
Under these circumstances a true association may be lost in an independent sample.
Therefore, MDD cases could exist within the controls where they could mask true association signals.
This is suggestive that a true association may exist but was not statistically significant in this sample.
In such cases, the sliding-window approach of HAPLIN should have a better chance of detecting the true association.
We have already considered the possibility that the current study was inadequately powered to detect a true association.
FPRP is defined as the probability of no true association between genetic variants and disease given the statistically significant finding.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com