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With subsequent dosing, the trough tocilizumab levels plateaued by week 12 in both groups.
Serum trough tocilizumab levels increased more rapidly in the tocilizumab-SC group than in the tocilizumab-IV group (see supplementary figure S4, available online only).
Despite higher trough tocilizumab levels for tocilizumab-SC, the mean AUC and Cmax of tocilizumab at steady state were higher for tocilizumab-IV (see supplementary figure S5, available online only).
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Trough heparin (all species): Sample for trough heparin levels just before the next scheduled dose.
*Routine determination of trough serum levels is required.
However, a large variability in trough plasma levels has been observed [ 130].
The reference value for trough gentamicin levels after gentamicin infusion is < 0.5 mg/L.
Trough vancomycin levels greater than 15 μg/ml were associated with significantly more nephrotoxicity.
Gentamycin and amikacin peak and trough plasmatic levels were routinely checked.
Blood was sampled for peak and trough aFXa levels (5 days).
After 1 year, trough blood levels were targeted between 6 and 8 ng/mL.
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