Sentence examples for trough plasma levels from inspiring English sources

Both PET response and clinical benefit correlated with trough plasma levels of sunitinib and its principal metabolite (SU12662).

However, a large variability in trough plasma levels has been observed [ 130].

The tested predictive (independent) variables included: pShift change from R0 to R7, sorafenib trough plasma levels, its active metabolite M2-N-oxide trough plasma levels on R7 of run-in phase, and sorafenib dose on cycle 1 day 1.

These concentrations are below the abatacept trough plasma levels observed in patients receiving a clinically effective dose [ 1].

The mean trough plasma levels of dexverapamil and its major metabolite nor-dexverapamil were 1.2 and 1.5 microM respectively.

Doses of the respective CatK inhibitors for the rabbit Schenk assays were selected on the basis of trough plasma levels (Cmin) following oral dosing in the same species.

There is a correlation between imatinib trough plasma level and clinical response.

Therefore, the main purpose of this pilot study was to simultaneously evaluate the influence of genetic variations of CYP2B6, CYP2C19, and ABCB1, disease states, MDIs, and poly-substance use on the methadone steady-state trough plasma level and treatment responses in MMTP patients.

Simulations show that when the drug affinity to membrane-bound and soluble targets is the same, increasing the dose of trastuzumab to an 8-mg/kg loading dose, followed by a 6-mg/kg weekly dose, raises the trough plasma level of drug and achieves a higher target occupancy of the membrane-bound receptor.

Pharmacokinetic analysis of patients receiving 400 mg b.i.d., which was the dose selected for Phase II trials, showed mean peak-trough plasma levels of 3.6 and 1.7  μ M, respectively, with an apparent half-life of 15 h.

A total of 549 trough plasma VPA levels and concomitant total Hb levels were analyzed.