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Trough plasma concentrations in each subject prior to the study dose of medication for each period were determined to confirm steady state conditions.
Mean trough plasma concentrations were similar for generic and brand lamivudine and stavudine, but trough nevirapine concentrations were significantly higher with the generic formulation during period 2 (Table 2).
Cmin: colistin trough plasma concentrations at steady state.
Individual patient trough plasma concentrations were summarised per cycle and study day.
Steady-state trough plasma concentrations of sunitinib and SU12662 were observed throughout the study.
Response to treatment is related to nilotinib trough plasma concentrations [ 16].
Similar(22)
We found a median trough plasma concentration of 134.3 mg/L (IQR 65.3 201 mg/L).
Only ten of them reached the trough plasma concentration target of 20 to 50 mg/L.
Else, it was shown that colistin trough plasma concentration significantly increased between days 2 and 3, suggesting colistin accumulation with time as a result of slow systemic passage through the alveolar capillary membrane [9].
Owing to the distribution of the trough plasma concentration log transformation was applied.
However, they did find a relationship between trough plasma concentration (Ctrough) of erlotinib and skin rash.
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