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Trough drug levels were maintained in the range of 15 to 20 μg/mL.
Trough drug levels were still in the range of 15 to 20 μg/mL.
We monitored serum levels of amphotericin B in the patient and the ECMO circuit for standard peak and trough drug levels and when components of the circuit were changed.
Over the previous 4 months, two infected hemodialysis catheters had been removed, and for each episode, the patient had been treated with a 2-week course of intravenous (IV) vancomycin, with trough drug levels maintained in the range of 15 to 20 μg/mL.
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However, in NHL studies, trough circulating drug levels were < 100 ng/mL, therefore likely not impacting anti-InO antibody detection.
The pharmacokinetic profile of these agents showed reduced differences in peak and trough plasma drug levels, which allowed for more reliable drug delivery [ 5].
The trough CSF drug level at 50 mg was 0.5 to 1.2 ng/ml (0.9 to 2.2 nM).
Pharmacokinetic studies carried out in rabbits showed the absence of any sharp peaks or troughs in the plasma drug levels, and various levels of in vitro/in vivo correlation (IVIVC) were successfully established.
Trough plasma, CSF and brain drug levels were measured by tandem reverse-phase high-pressure liquid chromatography and mass spectrometry.
Measurement of trough drug concentration and of antidrug antibody levels has become essential for monitoring patients on these therapies.
In prior studies, there has been high variability in physician ordering practices of voriconazole levels, including random drug levels being checked rather than true trough levels [ 30].
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