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Blood was sampled for peak and trough aFXa levels (5 days).
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No protocol resulted in aFXa levels within the therapeutic range; peak levels were too high and trough levels too low.
Outcome measures: primary, achievement of target peak/trough levels of aFXa; secondary, monitoring the effect of concomitant administration of noradrenalin on aFXa levels.
After 12 and 24 h, 6% achieved antithrombotic aFXa levels.
Low antithrombin levels are associated with low aFXa levels during certoparin prophylaxis.
Three groups of patients were specified according to aFXa levels; AFXa levels of 0.1 0.3 IU/ml were considered to represent effective antithrombotic activity [ 21].
AFXa levels were determined 4, 12 and 24 h after injection of certoparin.
Additionally, risk factors associated with inadequate aFXa levels under standard certoparin dosages are evaluated.
We found a positive correlation between the dose of enoxaparin and aFXa levels ≤ 60 mg.
AFXa levels were measured before and 4, 12, 16 and 24 h after administration of certoparin.
Higher doses resulted in better peak aFXa levels, with a ceiling effect observed at 60 mg.
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