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Although children identified sleep as a troublesome activity, this is already included in the symptom domain of the AQLQ.
The DII-integral is domain-dependent for thermal mismatch interfaces, which is troublesome to thermal fracture analysis of composites with complex thermal mismatch interfaces.
Certain issues may be discussed in concert - a new dish, a troublesome employee - but typically the final word lies with the person whose domain it is.
Particularly troublesome at the time was the second processing step in the transmembrane domain (TMD) since intramembranecleaving proteases were only discovered more than a decade later.
To integrate nonhuman animals fully into the moral domain, we may have to adapt our conception of morality in some very troublesome ways.
But some may prove more troublesome: several synaptic proteins have an inherent tendency to bind curved membranes – especially BAR-domain proteins such as endophilin and amphiphysin (Mim & Unger, 2012).
MID is defined as "the smallest difference in score in the domain of interest which patients perceive as beneficial and which would mandate, in the absence of troublesome side effects and excessive cost, a change in the patients' management" [ 15].
Eliminating the cross term is essential for a consistent definition of the frequency domain causality, however the addition of the harmonic terms makes the prospect of removing the cross term rather troublesome.
CaCO3 is also troublesome.
This could prove troublesome.
This has been troublesome.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com