Sentence examples for troublesome daily from inspiring English sources

Both PPI-based pharmacological and surgical therapies fail to fall into the "ideal" treatment category PPI therapy is associated with a high refraction rate, troublesome daily administration and significant adverse effects while surgical fundoplication involves invasiveness and is associated with high cost and high risks of postoperative complications.

Daily cough and sputum, but not troublesome during daily life.

The primary endpoint was elimination of daily troublesome regurgitation or atypical symptoms.

The elimination of daily troublesome atypical symptoms was assessed by the RSI questionnaire (each individual atypical score ≤2) score.

Patients who reported daily troublesome regurgitation and/or atypical symptoms on daily PPIs underwent esophagogastroduodenoscopy (EGD) and 48-hr pH monitoring after a 'wash out' period of at least seven days.

Included were patients with daily troublesome regurgitation and/or atypical GERD symptoms (Montreal criteria) on PPIs, abnormal 48-hour ambulatory pH test defined as% time pH <4 greater than 5.3% of the total recording period [ 11] and a history of daily PPI use for at least six months.

Under the assumption that more than 70% of the patients allocated to the TF group would have their daily troublesome symptoms eliminated compared to ≤20% in the PPI group, and a two-sided α error of 0.05, the predetermined sample size would provide an 80% power to detect a significant difference between the two groups.

Have you had daily, persistent, troublesome dry eyes for more than 3 months?

Just before glandular function evaluation, patients answered some questions to identify dryness symptoms [ 6]: Have you had daily, persistent, troublesome dry eyes for more than 3 months?

One doctor wrote: "Since I first arrived... the most persistently difficult, troublesome and stressful element in daily life has been the IT, especially but not exclusively DMICP.

It should not be considered in patients with disease duration greater than 10 years, significant wearing-off with troublesome dyskinesia and whose total daily levodopa dose is more than 600 mg.