Not long ago, gene therapy seemed troubled by insurmountable difficulties.
The University of Königsberg, founded on his initiative in 1544, was long troubled by such difficulties.
The production was troubled, by technical difficulties with the new process CinemaScope and by the delays inflicted by Judy Garland's personal torments.
On his first workday back in Washington after a 10-day vacation on Martha's Vineyard and a day trip on Sunday to New Orleans, Mr. Obama spent part of the morning huddled with his economic team, then emerged in the Rose Garden for a hastily arranged appearance that was troubled by microphone difficulties.
Because this score can be troubled by methodological difficulties, e.g., the incomplete availability of baseline creatinine, we also calculated the RIFLE score based on urine production using an automated search for the 6- and 12-h time frame during which the smallest amount of urine was produced on the first day of admission [16].
"I am very troubled by my difficulty in trying to determine which was the better of the two deals".
In oral arguments on the securities fraud charge, Cedarbaum was clearly troubled by the difficulty of discerning Stewart's state of mind, an element of any fraud charge.
After exploring some ideas as an EIR with Battery Ventures, he noticed that not only were founders troubled by the difficulty of finding and hiring technical talent, but that these activities posed one of the great scaling challenges facing startups today.
"I have for some time now been deeply troubled by the growing difficulties faced by Christian communities in various parts of the Middle East," he said.
By May 1846, troubled by the financial difficulties at Brook Farm, Ripley had made an informal split from the community.
I can be upset or troubled by others' problems and difficulties, but I can also admire and be touched by people's efforts to make the best of a bad job without manic attempts to deny the pain, without shifts to superiority or to callous indifference as means of dealing with envy or a sense of inadequacy.
