Sentence examples for trophic deprivation from inspiring English sources

The short form is required for neurite outgrowth through the NF κB and MAPK/ERK pathways; however, FAIM-S is unable to protect neurons from death induced by trophic deprivation or DRs. Nonetheless, the neuronal long form of the protein does exert protection against TNFR1- and FAS-induced apoptosis.

We first established that at E12.5, prior to the onset of cell death caused by trophic deprivation, no difference in the amount of Ret-expressing MNs in the lumbar segments could be detected in any of the met mutant genotypes (met d/d, met 2P/2P and met 2S/2S ) compared to controls.

Similarly, arginase 1 has been shown to protect motor neurons from trophic factor deprivation.

Autophagy ensures metabolism of hematopoietic stem cells during trophic factor deprivation [ 73].

Trophic factor deprivation diminished the activity of the Akt survival pathway.

Recombinant sAPP α protected primary hippocampal neurons and SH-SY5Y neuroblastoma cells from cell death induced by trophic factor deprivation.

This effect is probably due to the inability of mouse cytokines to react with human receptors, leading to survival signal and trophic factor deprivation in transplanted human cells.

Overall, these observations suggest that Trim17 is specifically expressed in transcription-dependent apoptosis, induced by trophic factor deprivation, but not during transcription-independent apoptosis.

In particular, trophic factor deprivation models of neuronal cell death involve a sequential MAP kinase cascade including the MLKs (mixed lineage kinases), MKK 4 and 7 (mitogen-activated protein kinase kinases) and JNKs (c-Jun N-terminal kinases) 14– 20.

The crucial role of BIMEL phosphorylation in apoptosis has been reported previously for cell death induced by trophic factor deprivation [ 34] and diallyl trisulfide [ 35], although the dissociation of BIMEL and MCL1 was not observed.

Nevertheless, expression of cell cycle modulators persists after neuronal differentiation and is upregulated under stress conditions, such as trophic factor deprivation, oxidative stress and the presence of DNA damaging agents.