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Objective: The purpose of this study was to compare the cost-effectiveness of combined first-trimester screening for fetal Down syndrome with second-trimester maternal serum triple screening.
In a cohort of 170,394 women who underwent maternal serum triple screening in Ontario, Canada, between October 1995 and September 1998, 189 women received positive screening results for both Down syndrome and neural tube defects.
Study Design: A first-trimester screening approach that used nuchal translucency measurement and maternal serum screening was evaluated against second-trimester maternal serum triple screening in a hypothetic population.
Before it is too late, before you fritter your life away triple screening, take note.
Similar(56)
But the triple screen also has its limitations.
Live actors played in front of a panoramic triple screen on which the scenery was rear-projected.
And, as with age, the triple screen sometimes suggests a high risk of Down syndrome when none exists.
To detect one case of Down syndrome, 54 women with positive triple screens would have to undergo an amniocentesis.
the photographs that kept dissolving into one another on the triple screens, she seemed gay and self‐assured.
In the presence of normal genetic sonography, the risk for fetal Down syndrome was reduced by 83% in patients with advanced maternal age, 88% in patients with abnormal triple screen, 89% in patients with abnormal triple screen who were <35 years old, and 84% in patients who had both abnormal triple screen and advanced maternal age.
Serum tests include one for alphafetoprotein (AFP) or one for alphafetoprotein, estriol, and human chorionic gonadotropin (triple screen).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com