Sentence examples for triple deficient from inspiring English sources

To resolve this issue, E006AA cell subcutaneous inoculations into both intact male nude and NOG/SCID/γcnull triple deficient mice [i.e., NOG-SCID mice deficient in NK, B, and T-cells] were initiated [29].

The data from two Msh2−/−, four Msh2−/−Msh6−/−, three Msh2−/−Msh6−/−Msh3−/− mice, and their combined eleven littermate controls showed that the double and triple deficient B cells had ∼75% reduction in the frequency of switching to IgG3 (p<0.001) and ∼50% reduction in switching to IgG1 (p<0.001) compared to the control mice (Figure 3).

The triple deficient pro B cell line (Rag2−/−, λ5−/−, SLP65−/−) (TKO, Meixlsperger et al., 2007) is a kind gift of Hassan Jumaa.

To rule out that any activator BH3-only molecule is relevant for apoptosis upon Bcl-XL/Mcl-1 loss, we generated MEFs that are triple deficient for Bim, Puma and Bid.

Zhou and coworkers convincingly displayed this IRAK-M transmitted NF-κB activity in the murine system using IRAK-1/IRAK-2 deficientficells cells and IRAK-1/IRAK-2/IRAK-M triple deficient cells derived from knockout mice [ 13].

It will therefore be of high interest to analyze phenotypic and gene expression changes in adult APP/APLP2 double or APP/APLP1/APLP2 triple deficient brain, once viable conditional combined mutants become available that are currently generated by crossing mice with floxed APP and APLP2 alleles with transgenic tissue-specific Cre mice [ 56].

We evaluated the ability of NFV to inhibit the growth of NCI-H460 cells growing as xenografts in triple-deficient murine model.

A total of 10 male triple-deficient BALB/c nude mice at 6 weeks of age were purchased from JAPAN SLC. Inc. (Shizuoka, Japan), and were maintained in pathogen-free conditions with irradiated chow.

At one facility, most of these triple-deficient mice died perinatally, typically in a window between E17 and 1 to 2 days after birth, and no Shpn m/m Casp8 -/- Ripk3 −/− animals were obtained at weaning.

DOI: http://dx.doi.org/10.7554/eLife.03464.011 While the reason for the lethality of the triple-deficient animals is unknown, we were readily able to obtain viable Shpn m/m Casp8 +/− Ripk3 −/− mice.

TKO-MD is a pro-B cell line derived from RAG, Lambda5, SLP-65 triple-deficient mouse bone marrow which is transfected to express an IgM- and IgD-BCR specific for the hapten 4-hydroxy-5-iodo-3-nitrophenyl acetyl (NIP) (Meixlsperger et al., 2007).