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The inverse process (inverse-MIEK), when a triple changes state from the octupole to the quadrupole regime, can also occur.
The value of τ, representing the tendency for simultaneous multiple-base substitutions, indicates that the proportions of single, double, and triple changes are 99.4%, 0.58%, and 0.002% respectively.
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Yet his introduction with Jerome Thomas and Alexei Smertin in a triple change proved crucial.
Lambert gave his side 12 minutes of the second half to show some willingness and, when there was no change, he made his triple change.
Vale manager Micky Adams made a triple change shortly after City's second goal and, although substitutes Byron Moore, Jordan Slew and Mark Marshall impressed, they could not affect the final outcome.
Wenger made a triple change on the hour, sending on Kieran Gibbs, Lukas Podolski and Tomas Rosicky for Nacho Monreal, Olivier Giroud and the desperately poor Mesut Ozil.
Leicester made a triple change and it looked to have paid off when Tait played outside to Benjamin and the former Worcester winger dived over the line - with the try given after replays.
In particular, Pol ι D34 with a single amino acid substitution Asp34Ala, Pol ι D126A/E127A with a double amino acids substitution Asp126Ala, Glu127Ala, and the variant with a triple change were completely inactive.
The log-exchangeabilities of these codon pairs are significantly smaller than their log-odds, indicating that almost all substitutions of these codon pairs were estimated in KHG not to occur by triple nucleotide changes but rather by successive single or double nucleotide changes.
The weighting of these aspects in the theory of the "triple criterion" changes over history in complex fashions.
The log-odds values for the codon pairs requiring single, double, and triple nucleotide changes are shown in Figs.
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