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All pregnant mothers in second and third trimester from the villages were invited via midwives to participate in the study.
We recruit pregnant women in their third trimester from the WIC clinic.
Next, we subtracted 13 weeks (the first trimester) from the gestational age at birth to obtain the number of weeks in the remainder of the pregnancy.
A total of 832 pregnant women in their second trimester, from the two hospitals, were enrolled at an average of 18.5 gestational weeks (range: 13.1 27.7); of these women, 599 (72.0%) completed the second interview at an average of 37.1 gestational weeks (range: 32.7 41.0).
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We calculated the dates of the trimesters from the length of gestation.
The weight gain during pregnancy was estimated by subtracting the early first trimester weight from the last measured weight before delivery.
For a human study, Kim et al. (2011) recruited pregnant women from hospitals in three large cities in South Korea and analyzed 44 blood samples collected in the third trimester and from the cord at delivery.
A study done in South Korea, where pregnant women were recruited from three hospitals in large cities and their blood samples (n = 44) were collected in the third trimester and from the cord at delivery, reported inverse associations between maternal PFOS and cord T3 levels, and between maternal PFTrDA and cord T4 and T3 (Kim et al. 2011).
We defined first (from day 1 after conception assumed to be 14 days after last menstrual period to day 92), second (from day 93 to day 184), and third trimester (from day 185 to the end of pregnancy), and the full pregnancy (from day 1 to the end of pregnancy).
Again we also present conservative estimates by removing the women who only filled one prescription for the psychotropic of interest in the first trimester from both groups.
It is usually performed in the first trimester from fetal material obtained through CVS and is associated with an approximately 1% risk of miscarriage.
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