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CATHY CAME UP TO NEW YORK from her home in Harleysville for a checkup each month during the first trimester; for the rest of the pregnancy, she and I went to her OB-GYN in Pennsylvania.
The purpose of this study was to determine the role of the combined use of uterine artery Doppler velocimetry (UADV) and maternal plasma PlGF and sVEGFR-1 concentrations in the second trimester for the identification of patients at risk for severe and/or early onset preeclampsia.
Fetuses will be scanned in the first trimester for the estimation of gestational age and subsequently at monthly intervals for fetal biometry [ 17].
Table 2 shows the distribution of methyl bromide use for each trimester for the buffer distance of interest (5 km) and the three additional buffer distances used in sensitivity analyses (1, 3, and 8 km).
We focused on exposure to any nitrosatable drugs during the month before and after conception in relation to NTDs and during the first trimester for the other birth defects.
To assess the performance of angiogenic and antiangiogenic markers measured in the second trimester for the prediction of preeclampsia in women with type 1 diabetes, receiver operating characteristic analysis was derived from the logistic model, both with and without covariates.
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Lower birth weight was associated with exposure in the third trimester for PM10, the first and third trimesters for CO, the first trimester for NO2 and SO2, and the second and third trimesters for PM2.5.
The inverse association between ambient O3 levels and birth weight was stronger for exposure occurring during the second and third trimester for both the O3[24hr] and O3[10 6] average metrics (Table 3).
We also excluded observations in any trimester for which the individual was not present for at least one-third of the time.
Infection occurred during the first trimester for 15% of the infected women, the second for 59%, and the third for 26%.
Restricting antipsychotic exposure to the first trimester of pregnancy in the assessment of congenital malformations, and to the third trimester for consideration of the neonatal adaptation syndrome, no meaningful changes in the main results were observed (supplementary table S4).
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