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Approximately half of all leiomyomas grow during pregnancy, mainly in the first trimester because of rising oestrogen levels [95].
Polyhydramnios may be present by the end of the second trimester because of poor fetal swallowing, but fetal movement is usually preserved.
The whole foetus is covered by this technique, even in the third trimester, because of a large field of view (FOV) [12], which cannot be supplied by ultrasound.
The Doppler technique is not recommended in the first trimester because of the potential harmful effect of the heating of the tissues [15].
Methylene blue is contraindicated in the pregnant patients during first trimester because of known teratogenic effect of jejunal atresia due to of vasoconstrictive effects in blocking nitric oxide [43].
This recommendation was based on the assumptions that cardiopulmonary resuscitation is ineffective in the third trimester because of aortocaval compression, and that fetal and perhaps maternal outcomes would be optimized by timely delivery.
Similar(47)
In our analyses it was more difficult to evaluate any independent effects of the trimesters because of the high correlation in exposure between them.
Similarly, the use of relatively large temporal windows (semesters and trimesters), because of the difficulties in pinpointing the exact 1 2 week period in which animals were clinically ill, could have masked an actual effect.
It is likely that this critical window of time will also apply to human exposures in the third trimester because the timing of cellular development, as well as conducting airway architecture/cellular composition, in the rhesus monkey lung closely recapitulates that in humans (Table 1) (Burri 1997; Plopper and Hyde 2008; Tarantal and Gargosky 1995).
We chose the 3rd trimester because the majority of mothers were sampled in this trimester.
Cardiac structure was assessed in the second and third trimester because the small size of the 14-week fetal heart precluded measurement in the first trimester.
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