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Finally, the last level of the network includes the differentiation driver and repressor Tbx6 that triggers the terminal myoblast differentiation.
This observation supports the idea that, in normal development, the ecdysone pulse in late larvae/early pupae triggers the terminal differentiation of CCAP neurons (Richards, 1981).
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This created a cloud that blocked out sunlight for a long time and, it appears, triggered the terminal decline of three quarters of the species on Earth.
We recently demonstrated that myeloma cells are highly sensitive towards proteasome inhibitors due to their extensive rate of immunoglobulin synthesis, thereby triggering the terminal unfolded protein response (UPR) and apoptosis via endoplasmic reticulum (ER) stress.
This led Braak to postulate that a pathogen may breach the IEB to trigger Lewy pathology in the terminal axons of the enteric neurons, further spreading to the central nervous system via the vagal preganglionic innervation of the gut [ 11, 39].
Substrate binding to the C-terminal domain triggers the closure of the N-terminal domain coupled with tight encapsulation of the ligand, stabilization of the conformation of an active site loop containing Cys73 and expulsion of water molecules with concomitant desolvation of the thiolate base.
Our combined data shows the early LGM constraining the procurement activity at the sources; an increase in active human responses to the LGM cold phase; and changes in the land use of the source area in the terminal LGM triggered by the appearance of new lithic technology and the reorganization of mobility ranges.
Depolarization of the nerve terminals triggers the exocytosis of LDCVs which release their contents into the general circulation.
Squeeze the trigger while contacting the terminals on each side to see if the circuit through the switch is making a connection.
Indeed, Kondo et al. [ 32] demonstrated that a small peptide (pri) triggers amino terminal truncation of the svb protein, switching its activity from a full-length repressor to a cleaved activator, providing temporal control to the GRN of epidermal differentiation.
When the measurements fell outside the established limits, alerts were triggered via the PDA terminal and the clinical staff acted according to the medical condition of the patient.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com