Exact(2)
We show here using a reporter system in HeLa cells that let-7 triggers target mRNA deadenylation, which is evident before measureable translational repression and mRNA destabilisation.
Similar results were obtained when Gli1 was induced by SAG, a small molecule that binds directly to Smo and triggers target gene expression.
Similar(58)
Lindsay Oberman, a former graduate student of Ramachandran's, who now works as a postdoctoral fellow at Beth Israel Deaconess Medical Center, at Harvard University, has begun using a technology called transcranial magnetic stimulation — a technique that triggers targeted areas of neurons in the brain — to influence brain plasticity in autistics.
Altogether these results raise the question of whether viroids are also triggers, targets and even suppressors of the RNA silencing machinery of their hosts.
Often, activation begins with a Ca2+ signal that loads the Ca2+ binding site of the C2 domain and triggers targeting to plasma membrane PS and PIP2 lipids.
Combining biopolymers that are crucial for wound healing may provide opportunities to synthesise matrices that are inductive to cells and that stimulate and trigger target cell responses crucial to the wound healing process.
However, a similar observation was previously reported where low avidity TCR interactions in the absence of co-stimulation could trigger target cell lysis but not the production of cytokines (in that case, IL-2) [47].
It is known that miRNAs trigger target mRNA degradation (Huntzinger and Izaurralde, 2011).
In addition to mediating caspase-dependent apoptosis, granzyme B can trigger target cell death in a caspase-independent manner.
Following estrogen stimulation, both receptors migrated to the nucleus, a crucial event to trigger target gene transcription via the genomic pathway of the estrogen signaling cascade.
The Argonaute-miRNA are known to silence transcription, trigger target destruction, or inhibit translation, and growing evidence supports their role in germline development [ 11, 71].
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