Because RAGE forms dimers and higher-order oligomers, polyvalent engagement of MG-H proteins by RAGE results in tight binding and triggers RAGE-dependent signaling.
Hers is a funny and deeply involving story but its sharp stabs against the women-hatred of the Iranian governing classes are enough to trigger rage.
Perceived threats, real or imagined, can trigger rage.
Taylor has a rare condition known as misophonia, a neurological "glitch" where certain everyday sounds can trigger rage responses, suicidal impulses, and other intense reactions.
The high resolution structure of a S100B octamer has recently been reported and tetramers were proposed to trigger RAGE activation by receptor dimerization.
As already described, these conditions favor formation of 'advanced glycation endproducts', which can trigger RAGE and subsequently lead to sustained inflammation.
Third, among the broad spectrum of extracellular ligands that trigger RAGE signalling, many have been functionally linked with acute and chronic immune responses [ 24- 26].
On a deeper level, a doctors' inability to cure can threaten his or her fantasy of omnipotence and provoke a sense of inadequacy, and this can trigger rage or hatred toward the patient [ 19, 29, 50].
Plasma EN-RAGE triggers the RAGE pathway as proinflammatory ligand activating key inflammatory signals such as NF-κB and MAP kinase and stimulates cell adhesion molecules.
"We always thought we were the only family like this," Mr. Maharidge told me, meaning the hair-trigger rages, dinner-table screaming and terrorized children.
RAGE-mediated mechanism plays a role in ischemic myocardial injury through triggering RAGE-dependent cellular activation, inducing oxidative stress, and promoting inflammatory proliferative responses leading to vascular dysfunction [ 7, 8].
