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Progerin triggers loss of the heterochromatic marker H3K27me3, and premature senescence, which is prevented by telomerase.
Defective piRNA biogenesis (e.g., armi KD) triggers loss of Piwi, presumably as unloaded Piwi is unstable.
Aldosterone triggers loss of Rnf2 and these histone marks from the R1 R3 subregions of the α-ENaC promoter.
What triggers loss of mural smooth muscle cells and increased inflammatory cell infiltration in the intima-like (or neointima-like) unruptured sIA wall is unknown.
To determine whether H2O2-induced oxidative stress triggers loss of mitofilin protein expression in the ONH astrocytes and whether CoQ10 treatment prevents this loss, we examined the protein expression level of mitofilin using western blot analysis.
It has been previously reported that in cultured primary mouse megakaryocytes, deletion of Bcl-x or treatment with ABT-737 triggers loss of cell viability, Caspase-3/7 activity and a failure of proplatelet formation.
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Both of them triggering loss of pathogen control and inducing aberrant clinical consequences.
We conclude from these experiments that FasL is required for the TNFα triggered loss of RGCs.
Unilateral expression of TDP-43WT in postmitotic motor neurons for 6 days triggered loss of roughly 30% Isl1/2+ spinal motor neurons relative to the untransfected control hemicord (Fig. 5B).
Taken together, the results suggest that preferences of USP7 for specific PML isoforms underlies its ability to trigger loss of PML-NBs and proteins.
Acadesine triggered loss of cell metabolism in K562, LAMA-84 and JURL-MK1 and was also effective in killing imatinib-resistant K562 cells and Ba/F3 cells carrying the T315I-BCR-ABL mutation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com