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To achieve this goal, the authors used a method termed near-infrared photoimmunotherapy, where part of an antibody that recognizes Tregs is fused to a light-sensitive dye, and shining near-infrared light on the tumor activates the antibody and triggers killing of the Tregs.
In the case of T. gondii infection, the CD40 – CD154 pathway triggers killing of the parasite within macrophages that is dependent on the autophagy pathway [6], [8].
Employing biochemical, genetic and morphological studies, we found that CD40 upregulates the autophagy molecule Beclin 1 in microglia and triggers killing of Toxoplasma gondii dependent on the autophagy machinery.
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In 1986, an Iraqi airliner was seized by pro-Iranian extremists and crashed, after a hand grenade was triggered, killing at least sixty-five people.
ST. TAMMANY PARISH, La .-- Nathaniel Tillison told a jury he looked 1990s rap star McKinley "Mac" Phipps "dead in his eyes" and watched him pull the trigger, killing a man at a concert in 2000.
Hayne's workload and the scientific validity of his testimony have been criticized by numerous peers and colleagues over the years, culminating in a 2008 Mississippi Supreme Court decision (PDF) throwing out the murder conviction of 13-year-old Tyler Edmonds, who was accused of holding a gun with his sister and simultaneously pulling the trigger, killing his sister's husband while he slept.
CD40 upregulated Beclin 1 and triggered killing of T. gondii by decreasing protein levels of p21, a molecule that degrades Beclin 1.
The boy was unarmed, had pulled no trigger, killed no one.
The trigger kills the public health insurance option.
/ Pull the trigger, kill a nigga, he's a hero / Give the crack to the kids who the hell cares?
Then one day in October 1998, Hurricane Mitch hit Central America, flooding roads and triggering mudslides, killing an estimated 11,000 people.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com