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This phosphorylation triggers interaction with the SCFβTrCP (Skp, Cullin and F-boxβTrCP) E3 ubiquitin ligase complex, leading to polyubiquitylation and degradation of NUAK1.
Our findings suggest that PLK by phosphorylating NUAK1 at Ser and Ser triggers interaction with the SCFβTrCP complex resulting in ubiquitylation and degradation of NUAK1.
These results suggest that Src-catalysed Tyr-phosphorylation at Y460 of Tom1L1 triggers interaction with Grb2 that is also dependent on Y392.
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For our purposes, it is enough that microeconomic behaviour by the user triggers interactions with local quality of service through the formation of traffic flows.
These signalling pathways lead to phosphorylation of CREB (pCREB) at a conserved serine residue (Ser), triggering interaction with co-activators, including CREB-binding protein (CBP) or p300.
Plant hormones are invariably detected by a receptor protein, which triggers interaction of that protein with other proteins to elicit a signal transduction cascade leading to changes in cell activity.
In contrast, in the RIPA branch, IRF3 is activated by LUBAC-mediated linear ubiquitination, which triggers its interaction with BAX to cause mitochondrial activation and apoptotic cell death.
This in turn will likely lead to a conformational change in its cytoplasmic domain, which triggers the interaction with the downstream signalling components and thus induces the CWI response.
ZTL absorbs blue light with its LOV (light, oxygen, or voltage) domain, and absorbing blue light triggers the interaction with GI though the LOV domain.
Ca2+ binding to the regulatory domain II of cTnC first induces the opening of the N-lobe of cTnC, which then triggers an interaction with the regulatory helix 3 of cTnI.
GA binds to the nuclear localized GID1 receptor, triggering its interaction with the DELLA repressor.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com