M152R encodes an atypical serpin, the deletion of which triggers an attenuation of virulence in rabbit, associated with the absence of secondary myxomas (28 ).
To test the role of the BiP cysteine, we constructed a kar2-C63A ire1Δ double mutant overexpressing Ero1*, which would be expected to show a less pronounced translocation block if BiP oxidation triggers translocation attenuation.
Contrast medium injection was triggered by attenuation measurements in a region of interest (ROI) placed in the abdominal aorta at the level of the liver.
We conclude that the VSG-induced ES attenuation triggers the cell biological reprogramming of the parasite and causes the concomitant gain of full developmental competence.
We conclude that in the absence of the quorum-sensing factor SIF and at 37°C, the VSG overexpression-induced ES attenuation triggers G1-phase prolongation and concomitant expression of a bona fide stumpy marker in monomorphic slender stage trypanosomes.
Upon activation, these proteins act in concert to trigger a transient attenuation of protein synthesis, degradation of misfolded proteins and up-regulation of ER folding functions.
This is supported by several reports showing that persistent transcription-blocking lesions trigger somatic growth attenuation in order to switch physiological status from somatic 'growth' to 'maintenance' in an attempt to tolerate persistent transcription-blocking DNA lesions (32, 48).
The arterial and portal-venous phases are acquired at approximately 30 and 60 s after injection, respectively, often triggered by a specific attenuation threshold in a region of interest placed over the abdominal aorta [13, 14].
For the iterative approach, the total number of iterations is 50 with a mixing parameters (alpha) of 2; the original data were binned by 4. As N increases, the coefficient of variation (c_v) is first lowered (this corresponds to a decrease in the contrast), a trend only triggered by the artifact attenuation.
The production of high levels of antibody directed against the native conformation of mPrP resulted in prion disease attenuation without triggering T cells, thus avoiding autoimmune reactions.
