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In addition to binding to the androgen receptor, the new compounds seem to hinder it from getting into the cell's nucleus, binding to DNA, and triggering the expression of genes, the team reports.
Kir2.1 channel activity, which is responsible for this hyperpolarization, initiates myogenesis by triggering the expression of early transcription factors such as myogenin and myocyte enhancer factor (MEF2) [27].
The three-finger 3ZfFLO11/F2, with either VP16 or VP64, was effective in triggering the expression of the FLO11 gene to induce the phenotypic change.
It is tempting to speculate that cytoplasmic accumulation of toxic metabolites and/or metabolic signals due to the lack of RND-4 and/or RND-9 efflux pumps could produce a general stress response triggering the expression of genes involved in biofilm formation.
To resist attack by microbial pathogens, plants have evolved to recognize them, triggering the expression of diverse defense reactions.
The protein eventually enters the nucleus triggering the expression of several target genes that cause a transition from epithelial to more mesenchymal cells [ 559].
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Along with other stresses, heat stress can trigger the expression of certain genes that were not expressed under "normal" conditions [ 4- 6].
Low-temperature stress triggers the expression of chilling stress-associated genes.
The phytohormone ethylene triggers the expression of SUB1A and the SNORKEL ERFs, although they drive antithetical growth responses.
Further, the presence of phenolic constituents would have triggered the expression of ligninolytic enzymes by the fungi.
Liver ischemia/reperfusion injury triggered the expression of intrinsic PACAP and its receptors, whereas the hepatocellular damage was exacerbated in PACAP deficient mice [96].
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