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Recognition of cell surface ATP synthase at low pHe microenvironment contributes to intracellular acidification of EC known to induce cell death and the triggering of inflammation.
Altogether, this favors a decisive role of a pathogenic T cell response in the triggering of inflammation in gut mucosa and in postoperative recurrence.
The observation of a perifollicular infiltrate in the upper follicle near the infundibulum suggests that the primary causal event for the triggering of inflammation might occur near the infundibulum (Mahé et al 2000).
We suggest that SLE is the net result of an imbalance between these two systems, which is aggravated by the development of autoreactive antibodies, leading to the leakage of immune complexes from the circulation and the triggering of inflammation in the vessel walls and in the tissues.
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Among the alarmins, HMGB1 is a DNA nuclear binding protein that has recently been shown to be involved in the triggering of sterile inflammation [ 14].
This has clinical importance, as global tissue hypoxia has been associated with endothelial cell activation and injury, triggering of systemic inflammation, activation of the coagulation cascade, and multiorgan dysfunction [ 6, 25, 26].
Of special interest will be the implication of specific genetic aberrations in the triggering of ALL-inflammation setting.
The implication of specific genetic aberrations in the triggering of ALL-inflammation setting will be highly relevant to investigate.
We speculate that a multiplicative factor in our study could have been produced by triggering of regional lung inflammation with parenchymal cell activation and release of inflammatory mediators.
This process characterizes a metabolic endotoxemia and is considered as a triggering factor of inflammation and metabolic diseases.
Triggering factors of inflammation may be dysregulation of inflammatory pathways (e.g., immune alteration associated with aging or genetic vulnerability), pathogens (e.g., bacterial or viral infection), environmental toxins (e.g., pesticides), and protein aggregates (e.g., α-synuclein (α-Syn)).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com