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But the locality of the GCI is the problem: depending on how we construct the length of the triggering expression, we obtain a GCI or a PCI.
IL-4 has also been implicated in triggering expression of FoxP3 on naive peripheral CD25−CD4+ T cells [47], and when secreted by Th2 cells, IL-4 supporthethe inhibition of PLP139 151-specific PLP139 151-specificproinflammatory
BZLF1 is a viral transactivator protein known to be directly involved in triggering expression of the lytic genes and downregulation of latent genes, culminating in cell death and release of infectious virions [15].
In liver fibrogenesis TGF-β is the most potent profibrogenic signaling factor triggering expression, accumulation and deposition of collagen [ 30].
These data suggest that TRAIL can enhance extracellular matrix production in fibroblasts by triggering expression of TGF-β, which acts in an autocrine manner.
In fact, it was shown that microbiota can influence immunity by triggering expression of C-type lectins [ 49] or controlling the Th1/Th2 balance [ 50].
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Elicitors released by Trichoderma spp. are also involved in triggering expressions of defense protein within the plant (Thakur and Sohal, [2013]).
Moreover, a specific ribozyme with the coding sequence of the diphtheria toxin A chain in place of the firefly luciferase selectively triggered expression of the cytotoxin in cells expressing HCV IRES and specifically activated apoptosis of the cells.
To exclude that expression of shRNA per se could trigger expression of IFN pathway genes, tumors expressing control shRNA were analyzed.
However, most of the small-molecules used to trigger expression of product or metabolic engineering product genes are incompatible with downstream processing regulations or process economics.
In human PH activated STAT3 (pSTAT3) was shown to directly trigger expression of the provirus integration site for Moloney murine leukemia virus (Pim-1), which promotes proliferation and resistance to apoptosis in SMCs.
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