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According to several investigators [ 31, 76, 86, 122], the most likely mode of action involved in the bactericidal activity of LAAOs is that hydrogen peroxide causes oxidative stress in the target cell, triggering disorganization of the plasma membrane and cytoplasm and consequent cell death.
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Thus, cellular disorganization triggered by Cdc42 depletion is not caused by disturbed recruitment of these junctional components to the plasma membrane.
During passage through the epididymis, the migration of the cytoplasmic droplet containing the nucleus triggers tail disorganization [ 5, 6].
The resulting retinal detachment has had documented damaging effects, triggering cellular stress response pathways, reactive gliosis, retinal disorganization, photoreceptor degeneration, and functional losses in vision [16], [17].
These free radicals have a high tendency to react swiftly with lipids, thus, triggering lipid peroxidation, a process that can lead to membrane disorganization and consequently reduces in membrane fluidity [ 45].
Knockdown of afadin in LMVECs triggered cell-shape alteration, disorganization of cell-cell contacts, reduction of VE-cadherin staining, and formation of thick F-actin fibers at the cells periphery.
Avoid triggering factors.
Therefore, in addition to influencing muscle contraction, the age-related damage and disorganization of sarcomeres could trigger changes in the localization and activity of sarcomere-associated signaling factors, which might in turn induce changes in other cellular compartments.
Loss of M6 triggered a number of developmental defects such as disorganization and even total disruption of the FE as revealed by the presence of gaps (Figs. 6A,B and S8; white arrowheads).
"Trigger happy".
Land mines are triggered.
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