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Elevated cGMP is proposed to result in sustained increases in OS Ca2+, triggering death.
Treatment with Bf 140 nM was highly toxic, triggering death in 40% of the cells within one hour.
This solution seems much reliable, despite the fact that some recent studies also found an autophagy-independent function of Atg5 in triggering death of cell [ 98].
These discoveries coupled with the opportunity to gain new insights into triggering death of pathogenic yeast, extend the potential utility of this tractable genetic model.
Similarly, impairment of NF-κB under positive selection circumstances might be sensed as a null signal, triggering death by neglect [ 22].
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This suggests that insertion of the second palp was enough to trigger death, even in the absence of a genuine female orb-weaver.
Loss or malfunction of key biomolecules may even trigger death of cells depending on the duration and intensity of stress.
Such rationally designed suicide RNAs efficiently triggered death of HPV-16-transduced or hepatoblastoma-derived human tissue culture cells without evidence for off-target cell killing.
Here we report a novel class of super-expandable smart nanogels that undergo nano- to micro-scale volume transition in response to temperature change, applicable for thermally triggered death of cancer cells.
The presence of a single condition is usually not sufficient to trigger death by cardiovascular disease (Zareba et al. 2001).
Our data suggest that ROS may trigger death of T cells offering an explanation for protection from autoimmunity.
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