This system is highly regulated because it represents the final convergence signals which trigger competence development [ 29].
Given the conservation of the transformation machinery, it is of considerable interest to understand to what extent natural genetic competence can explain genetic variability by gene acquisition, at what frequency it occurs, and which signals trigger the competence state under specific environmental conditions.
The blp cluster is under the control of a complex set of regulatory sequences closely resembling the quorum-sensing (com) system, which triggers genetic competence in high-density populations of pneumococci.
The phosphate group is then transferred to the ComE, which in turn activates its target genes, including comX that encodes a competence-specific sigma factor recognizing a consensus sequence (com-box) at the promoter regions of late competence genes, triggering the signaling cascade for genetic competence [ 2- 5].
Welcome to hip-hop's Daptone era, triggering memories through extreme competence.
IFNγ triggers the listericidal competence of macrophages by up-regulating the small GTPase activity required for phagosome conversion [31].
Some participants appraised the PA program as challenging, providing an excellent opportunity to receive performance feedback; others were reluctant to expose their professional competence, triggered by feelings of performance anxiety.
(And really, what's a more historically male-dominated than the presidential primary field?) Deeming Michele Bachmann the Queen of Rage -- particularly in tandem with that admittedly crazy-eyes photo -- is bound to trigger certain negative-competence stereotypes.
This time could be related to the global triggering of uncontrolled immune activation, affecting residual immune competence preservation and HIV reservoir establishment.
The fact that developmental competence can be triggered in a strain that is supposed to be partly refractory to developmental progression is mechanistically intriguing.
In these bacteria, competence is induced by the competence-stimulating peptide (CSP) that triggers the process of transformation by interacting with its receptor ComD.
