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This activates the enzyme, triggering clotting.
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Because the substance is injected where blood would rarely go otherwise, it can deliver the healing instincts of platelets without triggering the clotting response for which platelets are typically known.
The chemicals released cause a sudden increase in permeability of the local blood vessels, the adhesion and activation of platelets (blood cell fragments that trigger clotting), which release their own active agents, the contraction of smooth muscle in the gut or in the respiratory tubes, and the secretion of fluids all of which tend to dislodge large multicellular parasites such as hookworms.
The rupture of plaques triggers clotting within the artery, causing myocardial infarction.
Inflamed with immune cells, the resultant unstable plaques are prone to rupture like a volcano at any time, spewing toxic fat globs into the bloodstream and triggering deadly clots, causing cardiac arrest.
Thromboplastin triggers the clotting cascade through the extrinsic pathway via complexation of tissue factor and factor VII, and blood clots embolize to the lungs in this model, recapitulating the life-threatening clinical condition of pulmonary embolism (PE).
Phosphatidylserine-exposing erythrocytes may further trigger blood clotting and thus foster thrombosis [ 257].
However, initiation of inflammation response also triggers less clotting system and yields fibringenerated mediators of inflammation.
As expected, the protein-rich exudates in CVH interact with tissue factor to trigger the clotting system and deposit fibrin [ 40, 41].
Spontaneous plaque rupture may trigger intravascular clotting (Day et al. 2005) and may be a primary cause of thrombus formation in the onset of acute coronary syndromes (Ishibashi et al. 2003).
But in some susceptible individuals, it can trigger blood clots, strokes or heart attacks.
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