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To determine whether NO-release can be triggered by activation of the cyclic nucleotide signalling cascade, we examined NO-release from OSNs following application of the adenylyl cyclase activator forskolin (Figure 3C).
Extrinsic apoptosis is triggered by activation of the death receptors.
This process is triggered by activation of the BCR and CD40 [ 6, 7].
27, 28, 30, 71– 79 The type of intracellular mechanism triggered by activation of the receptors appears to be cell dependent.
In a study on developmental programming, Pincus and colleagues [ 66] propose that low levels of maternal progesterone, which can be triggered by activation of the HPA-axis, predict immune disorders, such as atopic dermatitis, in girls only.
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Since more than a decade, a subtle microscopic inflammation of the intestinal muscularis, triggered by activation of resident macrophages residing between the longitudinal and circular muscle layer of the intestinal wall, has been identified as key process in the pathophysiology of POI and endotoxin-induced ileus.
Harvey, C. D. et al. The spread of Ras activity triggered by activation of a single dendritic spine.
The first meiotic division is eventually triggered by activation of a gigantic ubiquitin protein ligase called the anaphase-promoting complex or cyclosome (APC/C) whose destruction of securin and cyclin B activates a thiol protease called separase that cleaves the kleisin subunit of the cohesin complex holding sister chromatids together (McGuinness et al., 2005; Kudo et al., 2006).
Lamellocyte differentiation can be triggered by activation of a number of signalling pathways including the JAK/STAT [9], [19], Toll [20] and JNK pathways [21].
Besides, researchers found that pristine G can induce cytotoxicity through the depletion of the mitochondrial membrane potential (MMP) and the increase of intracellular reactive oxygen species (ROS) [12], therefore triggering apoptosis by activation of the mitochondrial pathway [34, 44].
The response is triggered by the activation of the NFkB signaling module as a result of the formation of an activating signal associated with the binding of LPS to appropriate receptors.
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