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If EADs reach a sufficient amplitude they may initiate a premature AP (triggered beat) which may in turn precipitate into TdP (Eckardt et al. 1998, Killeen et al. 2007a).
A triggered beat was similarly described as a positive deflection in the smooth repolarization phase of the AP whose amplitude approximately matched the amplitude of the initial AP.
A triggered beat was similarly described as a positive deflection in the smooth repolarization phase of the action potential whose amplitude approximately matched the amplitude of the initial action potential.
These are oscillations of membrane potential that are a function of the preceding AP and which may generate a premature AP, and if of sufficient magnitude locally to cause a propagated wave of depolarisation can produce a triggered beat.
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My heart's painful, triggered beating began just a few weeks back into this summer, when New Orleans filled up with water again after a simple hard rain.
A significant suppression of EADs, triggered beats and VT occurred within 30 s.
Perfusion with 0.1 and 1 μ m propranolol suppressed all EADs, triggered beats and episodes of VT.
Afterdepolarizations and triggered beats can be difficult to verify in MAP even if recording quality is high and standardized.
Bradycardic Scn5a+/Δ hearts spontaneously showed multiple EADs, triggered beats and episodes of non-sustained VT lasting on average 15 beats (range 7 33 beats) (n = 7) (Fig. 1b).
We report that KN-93 indeed leads to a significant reduction of EADs, triggered beats and episodes of VT in the spontaneously beating hypokalaemic heart.
All spontaneously beating bradycardic Scn5a+/Δ hearts displayed EADs, triggered beats and ventricular tachycardia (VT; n = 7), events never seen in WT hearts (n = 5).
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