However, both groups exhibited similar increases in ROS in response to CD3/CD28 triggering alone and this suggests that sources of ROS other than NADPH oxidase are available during prolonged TCR signaling.
However, TCR triggering alone cannot sustain expression of Myc and post-transcriptional control of Myc protein by IL-2, a γc cytokine that triggers Janus-associated kinase (JAK -dependent signalling pathways, fine-tunes Myc levels in individual T cells.
We demonstrate that MSC SASP implements a full senescence response in young cells, suggesting the presence, in the pool of secreted molecules, of factors capable of triggering, alone and/or in combination, senescence mechanisms through autocrine/paracrine signaling cascades.
Surprisingly, the ITIM Y566F chimera, which has an unaltered ITAM-like sequence, augmented calcium mobilization over that of BCR triggering alone and thus disclosed FCRL5's potential for activation.
Fibrinogen alone did not induce AT complexes, and purified thrombin alone triggered only a minor generation in whole blood.
Lacking the first invader, the second invader alone triggered only a small fraction of spurious reactions (blue trajectory).
We found that TCR-stimulation alone triggered only a low level of Th17 cell proliferation, whereas the addition of the cytokine cocktail, along with TCR-stimulation, profoundly induced proliferation of Th17 cells and the accumulation of CFSElow Th17 cells among these CD4 T cells.
Monitoring of indicators of patients' needs, such as declining physical function, distress, repeated hospitalizations, or pre-defined thresholds of symptoms alone will trigger "only" further assessment [ 14].
Again, we found no difference when this analysis was performed on either spontaneous or thalamically triggered coactivations alone.
Triggers alone are not enough in order to get a user to take an action.
