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Binding of the PEX14 N-terminal to the most C-terminal W-X3-F/Y motifs has been shown to trigger unloading of the atypical PTS1-cargo catalase from PEX5 [24].
The 1 1 1 molar ratio of components in pull-down assays that allowed successful isolation of the ternary complex may have contained insufficient PEX14N to trigger unloading due to the higher PEX14N affinity of the N-terminal W-X3-F/Y motif of PEX5 [12].
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He says that "climate change is driving rapid melting of ice on many volcanoes worldwide, triggering unloading as ice is removed.
This study was designed to investigate whether, in patients with hypertrophic cardiomyopathy (HC), tilt-induced volume unloading triggers a peripheral reflex similar to that seen in patients with a history of vasovagal syncope or rather acts through an intrinsic cardiac mechanism secondary to diastolic dysfunction.
These observations support the hypothesis of glacial unloading triggering enhanced volcanism (Huybers and Langmuir, 2009; Watt et al. 2013).
The stepping down movement of the leading leg was triggered while the unloading phase (peak-Tbal, Fig. 2) was being performed, before the M/L CP shift was completed.
Post-surgery, stepping down is triggered largely before the unloading is completed (sound supporting leg: -514 ms +/-60; operated supporting leg: -492 ms +/-176).
To test this hypothesis, in rat ventricular myocytes undergoing prolonged mechanical unloading, we measured the trigger for Ca2+ release (ICa,L), and SR Ca2+ release (the whole-cell Ca2+ transient and Ca2+ sparks).
Numerical modelling indicates post-glacial unloading as the main triggering factor of the slope deformation.
This type of rockburst, which is called gas outburst rockburst, is triggered by the coupling between the unloading of the porous material and the gas storage structures and the expansion due to desorption of methane gases.
It remains unknown whether these changes are directly caused by the osteoarthritis process triggered by IA or are caused by unloading of the joint (due to pain); it has been suggested that oestrogen deficiency may exacerbate pain perception [ 47].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com