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For example, a chemical mentioned in a metabolic pathway paper may not be the molecule that can trigger the pathway, rather it might be an inactive chemical compound, related to the methodology, or a substrate mentioned in a longer protein name or gene name.
An important question concerns the actual signals that trigger the pathway.
Eliminating low frequency signals means constant stimuli, whose frequency can be considered as 0, is not able to trigger the pathway.
Disruptions expected to interfere with the death pathway mediated by the Fenton reaction were widely beneficial only in selections with aminoglycosides, even though all bactericidal antibiotics are thought to trigger the pathway [33].
The model incorporates EGF and T N F- α which are treated as stimuli that trigger the pathway response.
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Recent reports have shown that p53 activation can trigger the pathways that promote tau protein aggregation, which in turn is thought to reflect specific stages in Alzheimer's disease [ 10].
What triggers the pathway to start?
The results indicate that exposure of Huh7 cells to TD triggers the pathway of apoptosis leading to decrease in viability of Huh7 cells.
Previously, it was shown that acetate and butyrate addition triggered the pathway in C. acetobutylicum to shift from acidogenesis to solventogenesis (Li et al. 2011).
Disruption of the RB pathways could activate the ARF pathway, and the activation of ARF could trigger the p53 pathway, which induces growth arrest and/or apoptosis [ 41].
Gal-1-induced activation of the TCR ζ/Lck/ZAP70 pathway was proved to be essential to stimulate ceramide release and to trigger the mitochondrial pathway of apoptosis.
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