Consequently, although restoration of oxygen during the reperfusion period has an important benefit and activates some events that normally occur after hepatectomy, reactive oxygen species (ROS) and cytokines highly produced during ischemia lead to additional cell injury and trigger the apoptotic machinery in hepatocytes.
Here, the only direct contact of HBMSC and HUVEC was sufficient to stimulate the secretion of key soluble factors that are critical for self-assembled network structure: VEGF165 was upregulated in co-HBMSC, which in turn activated uPA through uPAR in co-HUVEC, probably triggering the proteolytic machinery and initiating the migration of co-HUVEC and self-assembled network formation.
They are important for critically triggering the metabolic machinery of glycolysis/gluconeogenesis by the conversion of food into chemical energy.
Transcription from repeated DNA sequences at the centromeres, mating-type region and telomeres especially during the S-phase of the cell cycle, triggers the RNAi machinery.
P450cin redox partner binding may not play as significant a role in triggering the catalytic machinery required for proton-coupled electron transfer.
Together these results support the view that viroids trigger the RNA silencing machinery of their hosts and are targeted by: i) one or more DCLs, which are secondary structure-specific and, ii) one or more Argonautes (AGO) forming the core of the RNA-induced silencing complex (RISC), which are sequence-specific [see for a review 15].
Since the accumulation of aberrantly processed mRNAs will trigger the nuclear degradation machinery, nuclear accumulation might not be in proportion to the level of reduction of processed mRNAs.
We detected p38MAPK phosphorylation in MT103-infected cells mainly at early time points post infection, suggesting that this is an early event necessary to trigger the subsequent apoptotic machinery.
In S. cerevisiae deficiencies in the ESCRT machinery trigger the mistargeting of endocytic and biosynthetic ubiquitinated cargoes to the limiting membrane of the vacuole.
Given the possibility that E650 may be involved in the transduction of conformational changes associated with calcium binding to trigger the channel's gating machinery, it will be important to further scrutinize its functional role in future studies.
