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For AVMs, Galletti et al. showed the location of AVMs to be significantly associated with migraine-like headache presentation, leading the authors to suggest that hemodynamic and structural changes caused by AVMs in the occipital lobe may trigger spreading depression and thus migraine [5].
Immunization of experimental rabbits and mouse models with the proline-rich peptide PPPGMRPP, another key sequence, which is present in several spliceosomal proteins and was reported to trigger spreading in immunized animals [ 32, 33], gave contradictory results in independent studies regarding the presence or not of anti-DNA antibodies and signs of lupus-like autoimmunity [ 34- 36].
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One hypothesis suggests that the process begins with a series of destabilizing events within the brain that trigger cortical spreading depression (CSD) [28].
"Clearly the distress or failure of some of these banks could trigger reactions spreading broadly to the financial system," former Federal Reserve Chairman Paul Volcker wrote in a letter to Brown.
At the same time, they are also the Achilles' heel [42] of the global economic system in the sense that their failure would trigger the spreading of a worldwide crisis, leading to an almost complete failure of the global economic system.
A few euchromatic F and roo insertions did, however, trigger H3K9me3 spreading in a Piwi-dependent manner.
One attractive hypothesis is that methylation of the edge for example, at transposons such as Alu and B1 or at simple repetitive sequences as shown in E-cadherin and GST-P (Graff et al, 1997; Yates et al, 1999; Millar et al, 2000) serves as a trigger for spreading methylation into the centre of the region.
Recently, Nozari et al. [8] demonstrated that microemboli triggered cortical spreading depression without causing microinfarction in a mouse model.
According to recent studies, microembolization might provoke a decrease in cerebral oxygen saturation, thus triggering cortical spreading depression and, thereafter, migraine with aura attack.
Taken together, we suggest that the post-adhesion process triggered hepatocyte spreading on glycopolymer surfaces, and ASGPR carbohydrate interactions act negatively on the post-adhesion mechanism as well as on hepatocyte spreading on glycopolymer surfaces depending on the density of coated glycopolymers.
These data suggest activity of the miRNA (or miRNA*) binding to miRNA* (or miRNA) sites which triggers transitivity (spreading of siRNAs) in both directions on both strands.
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