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Cut the trigger slit.
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In comm mutants, endogenous Robo1 is inappropriately trafficked to the growth cone plasma membrane in pre-crossing commissural axons, triggering premature Slit repulsion and preventing commissure formation.
In this previous study, considering the commercially available running wear jacket and the suggestions in the previous studies, three slits were applied: a. a shoulder slit that covered the trigger point and deltoid muscle, b. a mid-back slit that crossed the back muscle and erector spinae, and c. a lower-back slit that linked latissimus dorsi and the gluteus maximus.
Thus, as for netrins [18], ephrins [17], [30] or slit [31], a protease activity appears to be required to trigger appropriate guidance cues signalling pathways, hence placing proteolytic activity as a key actor of nervous system wiring.
Nephrin, a podocyte-specific protein contributing to functional stability of the slit diaphragm, is involved in podocyte shedding as recombinant endothelin triggers nephrin loss from human podocytes, which is prevented by ETA receptor antagonists [ 123].
Only slit.
Trigger, trigger!
I slit it open.
I slit her throat.
He slit his wrists.
Why the slit?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com