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So new ways to reconnect severed nerves and to trigger repair and regrowth are of considerable interest.
To ensure correct DNA replication, eukaryotes have signaling pathways that respond to replication-associated DNA damage and trigger repair.
While hyperoxia may increase reactive oxygen species production, resulting in oxidative damage, contradictory data show that hyperoxia can trigger repair mechanisms and increase antioxidant capacity.
There is recent evidence to suggest that the phagocytic clearance of myelin debris is required to prevent a detrimental effect of these debris on the brain and to trigger repair [ 22].
Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) have been successfully employed in Drosophila to generate DSBs in genomic targets that trigger repair by either HR or error-prone nonhomologous end joining (NHEJ) (Bibikova et al. 2002; Liu et al. 2012).
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Analyses of proteins interacting with cytosine-oxidized forms have identified glycosylase and DNA repair proteins interacting with 5-fC at a higher level compared with other cytosine forms, suggesting that 5-fC may trigger repair-associated removal [ 44].
Another non-mutually exclusive model suggests that DNA damage within the repeat tract triggers repair, which is, in turn, error-prone due to secondary structures formed by these sequences5.
Upon exposure, subendothelial collagen immediately binds to several molecules from the blood plasma, triggering repair, coagulation and thrombocyte binding.
Two-end DNA DSBs created by site-specific I- SceI endonuclease overexpression in mammalian cells triggers HR repair by short gene conversion [ 20], whereas spontaneous HR, most likely occurring at replication forks, triggers repair via a SCE [ 21, 22].
While mild heatshock treatment triggers repair mechanisms and centrosome thermotolerance severe heat shock leads to cell death by a mitotic catastrophe mechanism.
By this model, YKL-40 levels should be low in pre-renal AKI but relatively high when overt structural kidney injury triggers repair mechanisms and contributes to clinical outcomes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com