Sentence examples for trigger receptor from inspiring English sources

We hypothesised that unlike rhTRAIL, agonistic DR4/5 antibodies do not trigger receptor internalisation resulting in JNK activation in a different cellular compartment.

Moreover, membrane-bound ephrins trigger Eph receptor phosphorylation, while soluble forms can bind to Eph receptor, but do not trigger receptor activation [ 50].

However, these antagonists do not affect either the agonist-stimulated interaction of PAR2 with beta-arrestin or the ability of PAR2 agonists to trigger receptor internalization [ 254].

In detail, the ligand binding to the carboxy-terminal LRR region of cytosolic receptors of the NOD-like family (NALPs/NLRs) can trigger receptor clustering, recruitment and activation of initiating caspases, release of IL-1R and IL18 citokines, inflammation and inflammatory cell death (pyroptosis).

Specifically, D2L receptor activation recruits c-Src to transactivate the PDGF (platelet-derived growth factor) receptor and downstream Ras/Raf/MEK (MAPK/ERK kinase)/ERK signalling cascade, whereas D2S receptor activation may trigger receptor internalization and subsequent β-arrestin/dynamin-dependent Raf/MEK/ERK signalling (Schubert and Duronio, 2001; Kim et al., 2004).

Although it was shown that the antagonists did not trigger receptor internalisation in SST receptor-expressing cells a feature that was previously thought to be a crucial characteristic for good retention of tumour radioactivity tumour values were reported to be higher for the antagonist than for the agonist.

The pH triggered reorganization of helices α4, α5 of SCARB2 open, activate the lipid-transfer tunnel, and facilitate expulsion of viral "pocket factor" to trigger receptor-induced uncoating of the viral capsid (Fig. 6C and 6D).

To improve the targeting of the gene carrier for efficient cancer therapy, specific ligands which can bind to target cell-surface receptors, such as peptides, folate and antibodies, have been coupled to gene delivery vectors, which can trigger receptor-mediated endocytosis [22 24].

The sharp taste comes from chemicals that trigger receptors on pain nerves.

Both groups were more active after exposure to violence.| Chemicals used in flame retardants, and lubricants, and plastics may trigger receptors in human cells that are linked with obesity, and they may get into human systems through house dust.

Intracellular targeting is feasible through the use of ligands that trigger receptor-mediated endocytosis.