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"The trigger for intervention is lower and the pool of treatable patients is larger," said Dr. John D. Birkmeyer, director of surgical outcomes research at the University of Michigan and a co-author of the journal article.
Growth rate of renal tumors is believed to be the main trigger for intervention during AS.
A goal-directed approach using low fibrinogen levels as a trigger for intervention could improve outcomes.
Using oliguria in isolation as a trigger for intervention in ICU might lead to some patients receiving unnecessary intervention and other patients not receiving potentially helpful intervention.
Use of oliguria alone may be insufficiently precise to be used as a trigger for intervention in trials of novel protective interventions.
In addition to low MAP there was also another trigger for intervention in this group: if ScvO2 dropped below 75%% or there was a sudden decrease by more than >3 %, patients received a fluid bolus regardless of the MAP.
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Despite the cumulative evidence on the prognostic value of StO2 in trauma, with its potential use for early identification of at-risk patients, to this day, there is a lack of prospective studies exploring the usefulness of StO2 in trauma resuscitation algorithms, either as a trigger for interventions or as a target in the hemodynamic resuscitation process.
Companies have an obligation to establish what I call a, "Use and Abuse Policy," which sets certain triggers for intervention and helps users retake control.
Whilst Swigris [ 5] and Schoenheit [ 18] reported the impact of symptoms on health related quality of life, less attention has been paid to timing of assessments and triggers for intervention.
The best way to deflect those challenges may be to ensure that, in any attempt to make levels of predicted risk trigger points for intervention, the intrusiveness of the intervention is well matched to the confidence of the prediction.
Therefore, the composite effect of the accumulation of potentially removable toxins, where non-excreted fluid can also be regarded as a 'toxin', rather than any single parameter seems to define the trigger point for intervention.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com