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In all these calculations the trigger exposures were assumed to be discrete and their effect periods not to overlap.
We believe this may be an explanation why some MH susceptible patients develop a MH crisis while others never or only after several trigger exposures suffer from MH despite a proven in vitro susceptibility.
Exposed person-time was estimated as usual annual frequency multiplied with the assumed length of the hazard period (B, C, D) implicitly making the conservative assumption that all trigger exposures occurred during time at risk.
Similar(57)
Present projects include development of on-line tools to generate detailed patient histories and delineation of diagnostic impressions based on established criteria, and app-based tools for monitoring headaches, trigger exposure, lifestyle decisions and integrating them with predictive modeling, deep phenotyping, and big data to help patients and their doctors to better manage headache disorders.
Exposed time was determined from reported episodes of trigger exposure and calculated as the sum of the time at risk during each hazard-period following an episode of trigger exposure.
If the expected odds of trigger exposure are independent of whether the case is at risk of falling or not the effect estimate would be the same.
In (E) we instead explicitly assumed that trigger exposure occurred independently of whether the person was at risk of falling or not.
Had we not had information regarding this time at risk we would have been limited to basing the exposed time on the reported usual frequency of trigger exposure.
Notably, NMR data revealed that binding of a soluble derivative of PtdIns(4,5 P2 to MA triggers exposure of the myristic acid moiety covalently linked to the N terminus of MA11.
This is likely explained by similar triggers exposure for both genders in our study are stress, irregular sleep, reading hours and exams.
PtdIns(4,5 P2 interacts directly with hydrophobic residues in the matrix domain of Gag and triggers exposure of the N-terminal myristic acid [21], an event that is important for membrane-binding [62], [64], [87], [88].
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