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The technical characteristics of this set-up make it possible to trigger excitation without action potentials in the proximal part of the nerve fibres (by agonist superfusion of the coeliac plexus) and to block it downstream by selectively superfusing with drugs the compartment containing the main part of these fibres.
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Innovatively, a very easy method is designed to combine a long range diffusion triggered excitation and a great steric hindrance effect, which makes it possible to become a general sensing method.
Therefore, this study confirms in whole heart previous observations in cultured myocytes monolayers and validates the similarity of downstream effects of ectopically triggered excitation, regardless of stimulus nature, as had been assumed in previous conceptual and computational modelling.
Mechanical stimulation too early or too late for such overlap to occur was either inefficient in triggering excitation, or resulted in a single ectopic beat with no sustained, repetitive activation.
Let us consider the example shown in Figure 1B where spikes from two presynaptic neurons trigger an excitation PSP in a postsynaptic neuron.
Nevertheless, two main classes of models (Hill and Prejean 2015) are used to explain the triggering by dynamic stresses: (1) direct triggering by frictional failure and (2) triggering through excitation of crustal fluids.
Not to mention that it triggers sexual excitation in adults.
Transmembranal Ca2+ influx is an important initial trigger for excitation-contraction coupling in adult cardiomyocytes [9] and in hESC-derived cardiomyocytes (hESC-CMs) [19].
This is because silicon has an indirect bandgap; one must use a wavelength of approximately 360 nm (3.43 eV) to trigger direct electronic excitation of silicon.
We hypothesized that a peripheral trigger with ectopic excitation may have contributed to the clinical picture of SUNCT in this patient.
Moreover, different stimuli that promote neuronal excitation trigger the accumulation of these gene transcription regulators in the nucleus, although it is still unclear whether they are the same ones activated at distant parts of the neuron.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com