Sentence examples for trigger degeneration from inspiring English sources

Here we report that inflammation can trigger degeneration of dopamine (DA) neurons in an animal model of Parkinson's disease.

The MPTP acute mouse model trigger degeneration of nigro-striatral dopaminergic neurons along with significant brain inflammatory response [ 36, 37].

This then binds DR6 to trigger degeneration through caspase 6 in axons and caspase 3 in cell bodies [ 10].

Reduced ena levels triggered degeneration in the brain; interestingly, only the optic lobe was particularly vulnerable to ena downregulation, developing aged-dependent vacuolization, which correlated with a progressively poorer performance in a phototaxis behavioral paradigm.

AF64A is a chemical that preferentially triggers degeneration of cholinergic neurotransmission.

Thus, removing NPC1 function from neurons of adult P; N; Npc1 −/− mice triggers degeneration of neurons.

We can therefore conclude that, contrary to the standard hypothesis (Ilieva et al., 2009), intrinsic hyperexcitabilty is not an early event that triggers degeneration of the motoneurons.

The N-APP bound DR6, triggering degeneration of both neuronal cell bodies and axons depend on caspase-3 and caspase-6, respectively.

Since the F-type motoneurons are vulnerable in ALS whereas the S-type motoneurons are resistant (Pun et al., 2006; Hegedus et al., 2008), the remarkably selective intrinsic hyperexcitality of S-type motoneurons in neonates indicates that intrinsic hyperexcitability is not an early event that triggers degeneration of the motoneurons.

For instance, inhibition of Wnt β-catenin signaling Wnt β-catenining the mid and late signaling cortical neurogenesis suppresses neuronal production (Munji et al., 2011), witheas, in aDkk1 mice, it triggers duringrathen of striatal synapses and imidirs motor coordinandon (Galateet al., 2014).

We observe a similar phenotype when we trigger premature degeneration in these neurons.