Ceramide has been previously shown to trigger clustering of receptor molecules in the cell membrane; this clustering serves to initiate and amplify receptor-mediated signals (Grassmé et al, 2001).
Death receptor ligands, such as CD95 or TRAIL, trigger clustering of their respective receptors in the cytoplasmic membrane with recruitment of the adapter molecule FADD (Fas associated Death Domain) and pro-caspase-8 to form a multimeric death receptor-inducing complex (DISC).
In [22], the authors basically uses the ALM proposed in [21], with some modifications, as a criterion for triggering cluster re-organization.
Besides, a metric called the Aggregate Local Mobility (ALM) measure is considered to design a criterion triggering cluster re-organization strategy with a contention-based scheme in [17].
Over expression of OsbZIP23 in rice triggered clusters of genes regulating stress adaptations [ 33].
We propose the following model: tetherin-mediated virion retention triggers clustering of surface tetherin, targeting it for endocytic uptake.
The results of the current study provide genetic and pharmacological evidence in support of the hypothesis that Asm activity triggers clustering of integrins to mediate tumor cell-adhesion.
