In the clinic, trauma, contamination, degradation of the ACS, and exogenous BMP-2 can trigger an exaggerated inflammatory environment, which are characterized by the recruitment of inflammatory cells and stem cells to the implantation site and the secretion of various inflammatory cytokines in sera, such as TNF- α, IL-1 β, IL-8, and IL-6.
"The critical thing in the short term is that no incident be allowed to trigger an escalatory cycle, and the environment and structures be put in place that minimize the risk of an incident taking place at all".
Then, macrophages are activated by interferon-γ (IFN-γ) and, are able to control the intracellular growth of M. tuberculosis by triggering a hostile environment that includes acidification of the phagosome, lysosome maturation and production of NO and reactive oxygen/nitrogen intermediates.
Ratajczak et al. corroborated the significance of S1P in HSPCs chemotaxis by demonstrating that disruption of these interactions via CXCR4 antagonist AMD3100 or triggering a proteolytic environment in the BM would release HSPCs form their niches and therefore free them to follow the bioactive lipids' gradient to PB.
We have recently shown that IL-12 triggers an acute inflammatory environment that reverses dysfunctional antigen presentation by myeloid-derived cells within tumors and leads to an increase in the infiltration of adoptively transferred antigen-specific CD8+ T cells.
Nanoparticles interacting with cells and the extracellular environment can trigger a sequence of biological effects.
Hence, the model predicted that a sustained change in the environment would trigger a sustained change in body weight; the magnitude of the change would depend on the individual's inherited responsiveness to the factor.
Repeated exposures to concentrations above this NOAEC resulting in prolonged nerve stimulation (within hours) that might occur in working environments can trigger a response cascade leading to chronic adverse health effects.
A theoretical study of Boolean logic circuits with evolving architecture showed that forcing extinctions in a heterogeneous environment triggered an increased modularity of circuits, whereas the modular architecture did not develop in a homogeneous environment (Kashtan et al. 2009).
This is especially true for American college students, who navigate an environment that triggers an enormous amount of academic and interpersonal stress.
