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Apoptosis induction by the salubrinal/PSI combination was similar in range and kinetics to a proteasome/histone deacetylase inhibitor combination such as PSI and VPA, which represents a potent stimulus for apoptosis induction in Bcr-Abl positive and negative tumor cells [16], [36] [41] and may also trigger accumulation of unfolded proteins [42].
The chromosomal abnormality with BRCA gene mutation is thought to trigger accumulation of mutations and altered expression of oncogenes leading to tumor progression.
This lower β-glucosidase activity is thought to trigger accumulation of cellobiose, which is a strong inhibitor of cellobiohydrolase and endoglucanase activities during cellulose hydrolysis [ 9].
At a chromosome-internal locus, these breaks trigger accumulation of RAD51 foci, a G2/M DNA-damage checkpoint and repair predominantly by HR (Glover et al., 2008).
These germline mutations can also play a role in forming different subtypes of colorectal cancer, as they trigger accumulation of different sets of somatic mutations throughout carcinogenesis [ 22].
Addition of 10% human platelet lysate results in very fast proliferation of MSC-AT and this may further trigger accumulation of genomic aberrations [ 18].
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These results indicate that depleting monocytic MDSCs during IR + STING agonist treatment, which triggers accumulation of MDSCs, can further enhance radiation-induced anti-tumor immunity.
Heese and co-authors (2007) showed that INF1 also elicits a cell death response and triggers accumulation of reactive oxygen species (ROS) in N. benthamiana.
Paradoxically, knockdown of RPL23 itself leads to p53 activation, but at the same time it attenuates p53 induction by actinomycin D that on its own triggers accumulation of much higher levels of p53 protein than RPL23 loss [6],[6]].
Starvation triggered accumulation of autophagosomes in HL-1 cells.
Hypoxia-ischemia triggers accumulation of reactive oxygen species andintracellular calcium, which induces mitochondrial dysfunction.
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