Given the lack of transfusion trigger and a target haemoglobin concentration post-transfusion in this study, and a generous group upper limit of 90 g/L, would those patients with the lowest initial haemoglobin concentration not be likely to stay below that threshold despite transfusion?
Serpin structural remodeling is triggered when a target protease cleaves the serpin's solvent-exposed reactive center loop (RCL) leading to insertion of the cleaved RCL into the center of β sheet A in the serpin and translocation of the covalently attached protease ∼70 Å from one end of the serpin to the other.
DOI: http://dx.doi.org/10.7554/eLife.04066.001 Many living things have an immune system that is able to detect invading bacteria, viruses and other pathogens and trigger a response targeted against the threat before it causes lasting damage.
A novel and sensitive surface-enhanced Raman scattering (SERS) method is proposed for the assay of DNA methyltransferase (MTase) activity and evaluation of inhibitors by developing a target triggering primer generation-based multiple signal amplification strategy.
It is indeed often necessary to assay several amiRNAs, the sequences of which are based on computational predictions, to find one which effectively triggers knock down of a target gene (Warthmann et al. 2008).
Despite the cumulative evidence on the prognostic value of StO2 in trauma, with its potential use for early identification of at-risk patients, to this day, there is a lack of prospective studies exploring the usefulness of StO2 in trauma resuscitation algorithms, either as a trigger for interventions or as a target in the hemodynamic resuscitation process.
However current work in our lab suggests that cysteine-aspartate specific protease-like proteases (caspase-like proteases, CLPs) may act upon the actin cytoskeleton, suggesting the cytoskeleton may not be a initial trigger for PCD but instead a target of an upstream signal, although further research is required (data not shown).
There's Time Dash which lets you strafe at super speed away from an enemy's line of fire; you can combine this with Aim on the left trigger to target an opponent as soon as you come out of the move, making for a swift, super-efficient counter attack.
The chemical acts at a certain site, called the active site, triggering a biological response in a target tissue.
