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Previous studies have reported that statins can trigger a subset of tumour cells to undergo apoptosis (Jones et al, 1994; Dimitroulakos et al, 1999).
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The model features "reinforcement", rich-get-richer type dynamics with "triggering" whereby novel discoveries trigger the possibility for a subset of new discoveries.
Thus, the absence of Fbw7 appears to trigger abnormal differentiation of a subset of ductal cells, biasing them toward an endocrine fate.
Hence, these clinical observations suggest that PI3Kδ inhibition in CLL patients has effects on T cell subsets, triggering inflammatory reactions in a subset of patients.
Exogenous administration of the inflammatory cytokine interferon-alpha (IFN-α) can trigger a depressive episode in a subset of vulnerable people, though associated risk factors remain poorly understood.
Oxygen concentrations of 10%and14%4% may fail to trigger complete hypoxic arrest in a subset of embryos yet serve to slow development enough to cause problems.
Strikingly, as noted in our initial manuscript, the LT P-like stimulus used in our uncaging experiments usually triggers spine enlargement, but in a subset of LIMK1 knockdown and CCSS-LIMK1 rescue spines, instead triggers spine shrinkage.
This stimulus triggered synchronous calcium transients in a subset of the neurons in the field of view (Figure 4A).
This process has now been shown to be triggered by activating MOMP in a subset of mitochondria following sub-lethal doses of apoptotic stimuli [ 7], suggesting that the MOMP capacity of a cell can determine an apoptotic cell death versus oncogenic transformation decision event.
From our results, it is tempting to speculate that the proteins of the Bcl-2 family may trigger a common apoptotic pathway in a subset of inherited retinal defects resulting from excessive visual transduction.
AES provides the standard security guarantee and hence, is not susceptible to common attacks triggered by obtaining background knowledge of a subset of the data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com